Welcome To The Future – Snort Drugs? WRONG. Snort Stem Cells
Welcome To The Future! Where you’ll be snorting stem cells to fix your Alzheimer’s:
Via New Scientist:
STEM cells show promise for treating a range of neurological conditions, including Parkinson’s, strokes and Alzheimer’s, but it is tricky getting them into the brain. Perhaps inhaling stem cells might be the answer – if mice are anything to go by.
Other options all have their drawbacks. Drilling through the skull and injecting the stem cells is painful and carries some risks. You can also inject them into the bloodstream but only a fraction reach their target due to the blood-brain barrier.
The nose, however, might be a viable alternative. In the upper reaches of the nasal cavity lies the cribriform plate, a bony roof that separates the nose from the brain. It is perforated with pin-size holes, which are plugged with nerve fibres and other connective tissue. Since proteins, bacteria and viruses can enter the brain this way, Lusine Danielyan at the University Hospital of TÃ¼bingen in Germany, and her colleagues, wondered if stem cells would also migrate into the brain through the cribriform plate.
To test their idea, they dripped a suspension of fluorescently labelled stem cells into the noses of mice. The mice snorted them high into their noses, and the cells migrated through the cribriform plate. Then they travelled either into the olfactory bulb – the part of the brain that detects and deciphers odours – or into the cerebrospinal fluid lining the skull, migrating across the brain. The stem cells then moved deeper into the brain.
Hold on Nana! We got your ass, just uh, snort these cells.